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. 2020 Jan 21;39(4):379–388. doi: 10.1016/j.healun.2019.12.009

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© 2020 International Society for Heart and Lung Transplantation. All rights reserved.

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Exosomes from LTxRs with RVI induce a humoral immune response to lung SAgs. Serum samples collected on Days 10 and 30 from C57BL/6 mice immunized with exosomes isolated from LTxRs with RVI (n = 5) and from stable LTxRs (n = 5) were utilized to measure Abs to lung SAgs by ELISA. Serum samples collected on Day 30 from mice immunized with exosomes from LTxRs with RVI showed significantly increased Abs to SAgs (Col-V, 28.1 ± 4.0 vs 45.9 ± 6.5, p = 0.04; Kα1T, 230.4 ± 77.1 vs 604.6 ± 140, p = 0.04) when compared with mice injected with exosomes from stable LTxRs. The antibody development was compared between the cohorts using Student's t-test. Asterisk indicates statistically significant. Ab, antibody; Col-V, collagen-V; ELISA, enzyme-linked immunosorbent assay; Kα1T, K-alpha-1 tubulin; LTxR, lung transplant recipient; RVI, respiratory viral infection; SAg, self-antigen.