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. 2020 Jan 21;39(4):379–388. doi: 10.1016/j.healun.2019.12.009

Figure 6.

Figure 6

Exosomes from LTxRs with RVI induce cytokine-producing T cells to lung SAgs. Spleens were collected on Day 30 from C57BL/6 mice immunized with exosomes of LTxRs with RVI (n = 5) and from stable LTxRs (n = 5) were used to measure cytokine-producing T cells against lung SAgs by ELISPOT. Mice immunized with exosomes of RVI showed significant increase in T cells producing IL-17 and interferon gamma to SAgs. Mice injected with exosomes isolated from stable LTxRs showed increased frequency of IL-10–producing T cells compared with mice immunized with RVI exosomes. The cytokine levels were compared between the cohorts using Mann–Whitney test. Asterisks indicate statistically significant. ELISPOT, enzyme-linked ImmunoSpot assay; IL, interleukin; LTxR, lung transplant recipient; RVI, respiratory viral infection; SAgs, self-antigens; ** statistically significant.