Table 1.

Examples of human monoclonal antibodies isolated using the Cellclone Technology developed at Humabs.

Target	Findings	Reference
SARS	Potent and broadly neutralizing antibodies	Nat. Med. 2004; J. Virol. 2008
Diphtheria toxin	Sub-stoichiometric neutralization of the toxin	Unpublished
Anthrax protective antigen	Sub-stoichiometric neutralization of the toxin	Unpublished
HIV-1	Neutralizing antibodies targeting different sites including heptad repeat 1	PLoS ONE 2010; PLoS Pathogens 2010
Influenza A	Broadly neutralizing and pan-influenza A neutralizing antibodies	J. Clin. Invest. 2010; Science 2011; Nature 2014
HCMV	Extremely potent neutralizing antibodies targeting the gHgLpUL pentameric complex	J. Virol. 2010; PNAS 2014
RSV/MPV/PVM/BRSV	An antibody that neutralizes 4 paramyxoviruses	Nature 2013
Plasmodium falciparum	Antibodies to VAR2 CSA, MSP2 and p27. Fc-dependent killing of parasites. Novel antibodies targeting a conserved antigen on the blood stage of malaria	Mol. Microbiol. 2007; Infect. Immun. 2011; Nature 2016
Norovirus	Analysis of the GII.4 norovirus evolution	PLoS Path. 2012; J. Virol. 2014
Dengue Virus	Fc-engineered antibodies neutralizing all 4 serotypes and effective in an ADE mouse model	Cell Host Microbe 2010; PLoS Path. 2013
Rabies Virus	Potent and broadly neutralizing antibodies covering all seven lyssavirus genotypes	EMBO Mol. Med. 2016
S. aureus	Anti-MSCRAMMs and other target molecules antibodies with therapeutic potential	Unpublished
Avian Flu (H5N1)	Potent and broadly neutralizing antibodies	PLoS Med. 2007; PNAS 2015
Ebola	Potent antibody neutralizing Ebola virus as monotherapy in non-human primates	Science 2016
HBV	Potent neutralizing antibodies against HBsAg covering all genotypes and drug selected mutants	Manuscript in preparation
HCV	Potent and broadly neutralizing antibodies	Unpublished
MERS	Potent and broadly neutralizing antibody	PNAS 2015