Table 2.

Ribavirin resistant and sensitive variants. Unless otherwise indicated, mutations appear in the RdRp. The mechanism of resistance or sensitivity is indicated, when known

Virus	Variant	RBV phenotype — mechanism	Refs
Poliovirus	G64S/A/L/V/T	Resistant — higher fidelity	[33, 34]
FMDV	M296I	Resistant — RBV-specific	[44, 45]
	R84H	Resistant — higher fidelity	[36]
	A38V	Resistant — RBV-specific	[43]
	D5N:A38V:M194I:M296V (DAMM)	Resistant — RBV-specific	[43]
Coxsackie B3	A372V	Resistant — higher fidelity	[37]
	P48K, S164P, A239G, L241I	Sensitive — lower fidelity	[46•]
	I176V, I230F, F232Y, Y268W/H	Sensitive — lower fidelity	[46•]
	S299T	Sensitive — lower fidelity	[37]
HEV71	G64R/T	Resistant — higher fidelity	[35]
	L123F	Resistant — higher fidelity	[38]
Chikungunya	C483Y	Resistant — higher fidelity	[39]
	C483M	Resistant — higher fidelity	[47]
	C483A/G/W	Sensitive — lower fidelity	[47]
Sindbis virus	C482A/G	Sensitive — lower fidelity	[47]
HCV	J6/JFH1 resistant populations	Resistant to RBV and 5-FU	[41, 42]
	G404S, E442G in NS5A protein	Resistant to RBV	[40]
Coronavirus	MHV-ExoN-	Sensitive — lower fidelity	[51]
	SARS-ExoN-	Sensitive — lower fidelity	[48]
Influenza A	D27N in PB1	Resistant to RBV	[7]