Table 1.
ESCRT-dependent and independent budding of ssRNA enveloped viruses
| Species | Late domain | Virus protein | Cell protein | dn ESCRT | |
|---|---|---|---|---|---|
| (+) ESCRTa | |||||
| Rhabdoviruses | VSVb | PPPY (PSAP) | Matrix M | Nedd4 | VPS4 |
| Rabies virus | PPEY | Matrix M | Nedd4 | ? | |
| Filoviruses | Ebola virus | PTAP | Matrix VP40 | Tsg101 | VPS4 |
| PPEY | Matrix VP40 | Nedd4 | |||
| Marburg virus | PPEY | Matrix VP40 | Nedd4 | VPS4 | |
| PSAP | NP | Tsg101 | |||
| Paramyxoviruses | PIV-5c | FPIV | Matrix M | n.d. | VPS4 |
| Mumps virus | FPIV | Matrix M | n.d. | VPS4, CHMP4B | |
| Nipah virus | YMYL | Matrix M | n.d. | ?, VPS4 independent | |
| Sendai virus | YLDL | Matrix M | Alix | VPS4? | |
| Measles virus | ? | ? | ? | VPS4 independent | |
| HRSVd | ? | ? | ? | VPS4 independent | |
| Bornaviruses | Borna virus | ? | ? | ? | ? |
| Arenaviruses | LCMVe | PTAP | Matrix Z | Tsg101 | ? |
| Lassa virus | PTAP | Matrix Z | Tsg101 | VPS4 | |
| LCMV | PPPY | Matrix Z | ? | ||
| PPPY | Matrix Z | ||||
| Mopeia virus | ? | Matrix Z (NP?) | Alix | ? | |
| (−) ESCRT | |||||
| Orthomyxoviruses | Influenza virus | ||||
| Coronaviruses | MHVf | ||||
| SARS-CoV | |||||
| Budding with a protein coat | |||||
| Flaviviruses | YFVg | NS3 | Alix | ? | |
| JEVh | NS3 | Tsg101 | ? | ||
| Dengue virus | ? | ||||
| Hepaciviruses | Hepatitis C | HRS, CHMP4B | VPS4, ESCRT-III | ||
| Hepatitis G | |||||
| Pestviruses | Swine fever virus | ? | ? | ||
| Bunyavirusesi | Hanta virus | ||||
| Alphaviruses | SFVj | ? | ? | ||
| Rubivirus | Rubella virus | ? | ? | ||
(+) ESCRT-dependent; (−) ESCRT-independent binding; dn, dominant negative effect of ESCRT expression.
a
The description of late domains and ESCRT dependency of budding has been reviewed previously [75, 76, 78, 79, 81, 114].
b
Vesicular Stomatitis virus.
c
Parainfluenza virus.
d
Human Respiratory Syncytium virus.
e
Lymphocytic Choriomeningitis virus.
f
Mouse hepatitis virus.
g
Yellow fever virus.
h
Japanese encephalitis virus.
i
Bunyaviruses are split into five genera, Hantavirus, Nairovirus, Orthobunyavirus, Phlebovirus, Tospovirus.
j
Semliki Forest virus.