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. 2015 Aug 27;14:56–61. doi: 10.1016/j.coviro.2015.08.004

Figure 1.

Figure 1

Crystal structure of human CypA complexed with CsA (1CWA, pdb database, modified) and with coding non-synonymous PPIA gene SNPs. SNPs with accompanying amino acid exchanges introduced in Huh-7.5 PPIA manipulated cell lines [46] are Rs61747111 (D66E), rs17850033 (I89T), rs1059983 (E84D), rs11547706 (G96D), rs17850166 (N106I), rs9769523 (E134K). CypA is shown as a β-sheet structure with the SNP amino acids strongly, or only slightly affecting CoV replication in ball format, colored red and blue, respectively. Active site residues are depicted in orange. CsA binding to the PPIase active pocket of CypA is shown in green. The calcineurin-binding surface of CypA/CsA complex is indicated schematically.