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. 2020 Jan 29;161(4):bqaa009. doi: 10.1210/endocr/bqaa009

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© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Changes in the protein profile in placental exosomes present in maternal circulation across preterm birth gestation. Linear mixed modeling of all statistically significant proteins that change across gestation for preterm birth (PTB) pregnancies was performed. Linear mixed modeling in normalized protein abundance was performed on all of the statistically significant proteins (P < 0.05) that change across gestation for normal pregnancies, using the lme4 package in R. The data were scaled between 0 and 1 before hierarchical clustering analysis using Euclidean distance, which is displayed as a circular cladogram (generated using the ggtree package in R). Each color of the circular cladogram represents a different cluster and its trend, as shown in (A) through (N).