Table 1.
Protein changes within circulating exosomes PLAP+ve in A) across term pregnancy, B) across PTB pregnancies, and C) comparison between term and PTB across pregnancy, identified by information-dependent acquisition (IDA) and sequential windowed acquisition of all theoretical mass spectra (SWATH) were submitted to the Ingenuity Pathway Analysis (IPA) to determine the main signaling pathways associated with the protein profile within circulating placental exosomes.
| A)Changes in exosomes PLAP+ve across term pregnancies | B)Changes in exosomes PLAP+ve across PTB pregnancies | C)Changes in exosomes PLAP+ve between term and PTB across pregnancy | |||
|---|---|---|---|---|---|
| Top Canonical Pathways | pvalue range / #molecules | Top Canonical Pathways | pvalue range / #molecules | Top Canonical Pathways | pvalue range / #molecules |
| Acute Phase Response Signaling | 6.10E-08 | LXR/RXR Activation | 6.55E-15 | LXR/RXR Activation | 6.43E-06 |
| LXR/RXR Activation | 3.10E-05 | FXR/RXR Activation | 4.89E-13 | FXR/RXR Activation | 7.83E-06 |
| Top Upstream Regulators | Top Upstream Regulators | Top Upstream Regulators | |||
| IL-1 | 2.73E-09 | dexamethasone | 2.36E-06 | rosiglitazone | 2.00E-07 |
| L-triiodothyronine | 1.15E-06 | nitrofurantoin | 2.45E-06 | dexamethasone | 3.07E-07 |
| Top Diseases and Disorders | Top Diseases and Disorders | Top Diseases and Disorders | |||
| Inflammatory Response | 5.96E-03 - 1.62E-12 / 42 | Inflammatory Response | 8.68E-03 - 6.55E-09 / 32 | Inflammatory Response | 3.86E-03 - 1.28E-08 /31 |
| Metabolic Disease | 5.96E-03 - 1.62E-12 /24 | Cardiovascular Disease | 9.01E-03 - 1.70E-08 / 13 | Dermatological Diseases and Conditions | 2.17E-03 - 7.12E-07 /17 |
| Top Molecular and Cellular Functions | Top Molecular and Cellular Functions | Top Molecular and Cellular Functions | |||
| Cellular Function and Maintenance | 5.96E-03 - 3.61E-14 / 23 | Cellular Function and Maintenance | 7.73E-03 - 7.26E-10 / 20 | Cellular Movement | 4.10E-03 - 4.94E-10 /23 |
| Cellular Movement | 5.96E-03 - 1.41E-12 / 29 | Cellular Compromise | 7.32E-03 - 6.55E-09 /22 | Cellular Function and Maintenance | 4.12E-03 - 4.68E-09 /18 |
| Top Physiological System Development and Function | Top Physiological System Development and Function | Top Physiological System Development and Function | |||
| Immune Cell Trafficking | 5.96E-03 - 1.41E-12 / 25 | Humoral Immune Response | 4.88E-03 - 3.67E-07 / 8 | Immune Cell Trafficking | 4.34E-03 - 4.94E-10 / 19 |
| Humoral Immune Response | 3.42E-09 - 1.62E-12 / 10 | Immune Cell Trafficking | 8.68E-03 - 1.25E-06 / 18 | Hematological System Development and Function | 4.34E-03 - 3.82E-07 /20 |