Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 24;14:1209–1218. doi: 10.2147/DDDT.S227892

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Tsai et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Miconazole activates p62-KEAP1-NRF2 pathway in a time-dependent manner in bladder cancer cells. (A and B; upper panels) T24 and 5637 BC cells were treated with the increased time course of miconazole (25 μM), total proteins were extracted and expression levels of p62, KEAP1 and NRF2 were detected by Western blot. (C; upper panel) T24 BC cells were transfected with p62 siRNA or negative control siRNA for 24 h, followed by treated with miconazole (25 μM) for further 24 hrs, and expression levels of p62 and NRF2 were evaluated by Western blot. (A–C; lower panels) The relative band intensities of proteins presented in (A–C) were quantitated by densitometric scanning and are presented as the fold of control group; and the statistical calculation from blots of three independent experiments are shown (n=3). The results are presented as the means ± S.D; *P<0.05 compared with Con.; ^#P<0.05 compared with the miconazole treatment group.