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. 2020 Mar 24;13:2469–2481. doi: 10.2147/OTT.S240081

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© 2020 Wang et al.

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Bit1 Silencing contributed to the activation of the IL-6/STAT3 Signaling pathway. (A) Relative levels of Bit1, IL-6, IL-6R, and STAT3 mRNAs in different groups (Real-time PCR). The relative levels of mRNAs were evaluated according to 2^−ΔΔCt. (B, C and D) Various groups Western blotting assays for Bit1, IL-6, IL-6R, STAT3, and p-STAT3 protein levels. Control shRNA, Negative Control; Bit1 shRNA, lentivirus containing the cDNA sequence of Bit1; sh, short hairpin; Corylifol A. Inhibits IL-6-induced STAT3 activation and phosphorylation.*P < 0.05, ***P < 0.001.