Table 2.

HIF-1α, TWIST1, ITGB1, and Ki-67 Expression in the Three RCB Groups

Biomarkers (H Score)	Total	PCR+RCB-I	RCB-II	RCB-III	P value
HIF-1α	115.61±56.7	73.9±34.1	103.7±42.3	161.8±57.0	<0.001￥,a,b,c
TWIST-1	83.0 (58.5–149.0)	57.7±23.5	88.4±38.3	154.2±62.2	<0.001￥,a,b,c
ITGB-1	100.3±54.8	64.3±37.7	87.0±37.0	144.8±58.8	<0.001 ￥,a,b,c
Ki-67	67.6±46.1	112.7±62.7	67.4±29.8	36.6±19.5	<0.001￥,a,b,c

Notes: ^￥ANOVA test; ^asignificant difference for pairwise comparison between PCR+RCBI and RCBII; ^bsignificant difference for pairwise comparison between PCR+RCBI and RCBIII; ^csignificant difference for pairwise comparison between RCBII and RCBIII.

Abbreviations: PCR, pathological complete response; RCB, residual cancer burden; HIF-1α, hypoxia-inducible factor 1-alpha; TWIST-1, twist family BHLH transcription factor 1; ITGB-1, β1 integrin.