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. Author manuscript; available in PMC: 2020 Jun 16.
Published in final edited form as: Nat Mater. 2019 Dec 16;19(4):464–473. doi: 10.1038/s41563-019-0563-5

Extended Data Fig. 4. Lmna KO myonuclei with the highest amount of γH2AX foci frequently display chromatin protrusions.

Extended Data Fig. 4

Analysis of DNA damage, assessed by γH2AX staining, in Lmna KO nuclei, comparing nuclei with chromatin protrusions to those without protrusions. Chromatin protrusions were assessed based on the presence of chromatin extending beyond the nuclear envelope, marked by lamin B-staining. Data based on n independent cell lines per genotype. Significance determined by two-tailed students t-test. All bar plots show mean value ± standard error of the mean.