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. Author manuscript; available in PMC: 2020 Jun 16.
Published in final edited form as: Nat Mater. 2019 Dec 16;19(4):464–473. doi: 10.1038/s41563-019-0563-5

Extended Data Fig. 7. Inhibiting myofiber contractility does not prevent nuclear envelope rupture in Lmna KO myofibers.

Extended Data Fig. 7

(a) Quantification of cGAS-mCherry foci formation during 10 day myofiber differentiation follow treatment with nifedipine (5 μM), which inhibits contractility, or DMSO vehicle control, starting at day 5 of differentiation. Data based on three independent experiments. (b) Quantification of chromatin protrusions at day 7 of differentiation following treatment with nifedipine (10 μM) or DMSO, starting at day 4 of differentiation. Data points are from n images per genotype and condition, from three independent experiments. Significance determined by one-way ANOVA, using Tukey’s correction for multiple comparisons. All bar plots show mean value ± standard error of the mean.