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. Author manuscript; available in PMC: 2020 Jun 16.
Published in final edited form as: Nat Mater. 2019 Dec 16;19(4):464–473. doi: 10.1038/s41563-019-0563-5

Extended Data Fig. 1. Lmna KO and Lmna N195K have reduced contractility and experience nuclear loss.

Extended Data Fig. 1

(a) Quantification of myofiber contraction at day 10 of differentiation. Fibers were assigned contraction scores from 0 (worst) to 4 (best) based on the percentage of cells that were visually contracting. Data points indicate results from n independent primary cell lines for each genotype. Significance determined by one-way ANOVA, using Benjamini and Yecutieli (low power) multiple comparisons. (b) Quantification of the change in nuclear number between day 5 and day 10 of differentiation. Data points indicate results from n independent primary cell lines for each genotype. Significance determined by one-way ANOVA, using Tukey’s correction for multiple comparisons.