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. Author manuscript; available in PMC: 2020 Sep 25.
Published in final edited form as: Neuron. 2019 Jul 16;103(6):1056–1072.e6. doi: 10.1016/j.neuron.2019.06.013

Figure 6. Motor performance is dependent on DA and ACh availability.

Figure 6

A) The latency to fall from an accelerating rotarod increases over three consecutive trials. Motor learning is poor in DATdT-2w mice. For all panels, n=mice. B) The average latency to fall from the rotarod is reduced in DATdT-2w mice. C) Striatal DA content is depleted 12 hr following reserpine and is moderately reduced in DATdT-2w mice. D) ACh content is reduced in reserpine and DATdT-2w mice. E) The ACh/DA ratio is increased in DATdT-2w mice and rises further in reserpine mice. F) Latency to fall in control mice shows no correlation with striatal DA content, G) ACh content, or H) the ACh/DA ratio. Lines in panels F-K, linear regression. I) For DATdT-2w mice, the latency to fall positively correlates with striatal DA content and J) negatively correlates with ACh content and K) the ACh/DA ratio. L) The plot compares the latency to fall with DA content, M) ACh content, and N) the ACh/DA ratio. Bars, SE; &&p<0.01, 2-way rm-ANOVA.