Dopamine deficiency reduces striatal cholinergic interneuron function in models of Parkinson’s disease

. Author manuscript; available in PMC: 2020 Sep 25.

Published in final edited form as: Neuron. 2019 Jul 16;103(6):1056–1072.e6. doi: 10.1016/j.neuron.2019.06.013

KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-tyrosine hydroxylase	Sigma	Cat# Ab152
Biotinylated goat anti-rabbit IgG	Vector Labs	Cat# BA-1000
Elite ABC HRP	Vectastain	Cat# PK-6100
Chemicals, Peptides, and Recombinant Proteins
Diphtheria toxin	List Biological Laboratories, Inc	Un-nicked, Lot #: 15043A1
Reserpine	Sigma Chemical	Cat# R0875
Experimental Models: Organisms/Strains
Slc6a3^DTR/+ mouse model	Slc6a3^DTR/+ mice will be provided by Dr. Nigel Bamford, upon reasonable request.	None
B6.129S6-Chat^tm2(cre)Lowl/J mouse model	Jackson Labs	RRID:IMSR_JAX:006410
B6.Cg-Gt(ROSA)26Sortm27.1(CAG-COP4*H134R/tdTomato)Hze/J mouse model	Jackson Labs	RRID:IMSR_JAX:012567
B6.129-Rpl22^tm1.1Psam/J mouse model	Jackson Labs	RRID:IMSR_JAX:011029
Oligonucleotides
See Table S8 for primers used for RiboTag RT-qPCR	Invitrogen	See Table S8
See Methods for primers used for genotyping	Invitrogen	See STAR Methods
Software and Algorithms
Modified Robust Gaussian Surprise (RGS) code	MATLAB code will be provided by Dr. Nigel Bamford, upon reasonable request.	The code is also available at https://www.ncbi.nlm.nih.gov/pubmed/26866057