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. 2020 Feb 29;48(6):2866–2879. doi: 10.1093/nar/gkaa123

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Example of a multivariant association between TF binding affinity at CRMs and their target gene expression. (A) Genome browser representation of NR2F6 promoter distal interactions (represented by pink arches) as detected by PCHi-C (49) in LCL GM12878. The genome segmentation track for GM12878 based on chromHMM (80) is shown immediately below. CRMs at the distally interacting fragments (pale blue) and NR2F6 TSS-proximal window are depicted in azure blue. The distal fragment downstream of NR2F6 contains two CRM variants: one 44 kb away from the NR2F6 promoter and the other 19 kb away, predicted to impact SMC3 and SRF binding affinity, respectively, across the 359 LCLs. (B) Association between NR2F6 mRNA levels and predicted SMC3 and SRF binding affinity haplotypes.