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. 2020 Feb 12;48(6):3181–3194. doi: 10.1093/nar/gkaa093

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Sequences of hmtRNA^Ile and hmtRNA^Ser(AGY) are fine-tuned for t⁶A modification. (A) t⁶A modification levels of hmtRNA^Ile (black filled circles) and mutants G38A (red filled squares), G38C (cyanine filled triangles) and G38U (magenta filled inverted triangles) by YrdC/OSGEPL1. (B) t⁶A modification levels of hmtRNA^Ser(AGY) (black filled circles) and mutants A31G (blue filled squares), C39U (magenta filled triangles), A42U (red filled inverted triangles) and C39U/A42U (green filled diamonds) by YrdC/OSGEPL1. (C) t⁶A modification levels of hmtRNA^Thr/Ser (black filled circles) and mutants A31G (blue filled squares), C39U (cyanine filled triangles), A42U (magenta filled triangles) and C39U/A42U (dark green diamonds) by YrdC/OSGEPL1.