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. 2020 Feb 13;48(6):3366–3378. doi: 10.1093/nar/gkaa083

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — The TetR aptamer as versatile genetic device. (A) The TetR aptamer can activate TetR controlled gene expression by interfering with the DNA operator binding of the Tet repressor (10). Thus, it represents an alternative inducer to (B) tetracycline- or (C) peptide-mediated induction of TetR (26). (D) The aptamer also can be exploited to reversibly and efficiently control translation (24), (E) mRNA splicing (24) or (F) miRNA processing (22).