Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 31;48(6):3328–3342. doi: 10.1093/nar/gkaa062

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — The dimer interface of FANCA. (A) View looking down the dimer interface between the arc^C of FANCA CTD (orange) and the arc^N of FANCA’ CTD (green). Boxes contain clusters of contacts with their respective segments labeled. (B) Close-up view of the central interface in box b from (A). A view is orthogonal to the projection in (A). Black dotted lines indicate polar interactions. The interface is formed by the interactions between the H8B and the H8B’ helices and between the H8B’ and the H10B helices. (C) Close-up view of the interface between the H7B’ helix from FANCA’ CTD and the H9B, H10B and HM2C from FANCA CTD. A view is orthogonal to the projection in (A). The interface is formed primarily by the hydrogen bonds and polar interactions between the main chain and side chain. (D) Close-up view of the interface between the arch’ loop and the H11A and H12A helices in the same projection of (A).