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. 2020 Jan 31;48(6):3328–3342. doi: 10.1093/nar/gkaa062

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — The two interfaces between the FANCA and FANCG complex are required for nuclear transport of FANCA. (A) Structure of the FANCA–FANCG hetero-tetramer complex in two different views. The structure was reconstituted by aligning a FANCA CTD dimer of one FANCA–FANCG complex onto that of another complex. The EM map for the two FANCG molecules are shown in gray color. FANCA binds to the FANCG CTD via its C-terminal helical repeats and FANCA’ binds to FANCG’ through its NTD. (B) A cartoon representing a model by which disruption of either one of the two interfaces prevents the localization of FANCA into the nucleus.