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. 2020 Feb 27;48(6):2853–2865. doi: 10.1093/nar/gkaa126

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — MOE10-29 led to better therapeutic outcomes than PMO10-29 in severe SMA mice. (A) Survival curves after two SC injections of saline (n = 12), MOE10-29 (4 nmol/g, n = 14; 12 nmol/g, n = 14) and PMO10-29 (4 nmol/g, n = 14; 12 nmol/g, n = 14) between P0 and P1. (B) Body-weight curves after SC injections of MOE10-29 and PMO10-29 as in (A). (C) Representative pictures of high-dose MOE10-29- and PMO10-29- treated SMA mice on P60. (D) Tail length was measured weekly for up to 14 weeks (n = 12). (*) P < 0.05 high dose versus low dose of the same ASO; (^#) P < 0.05 versus all other groups.