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. 2020 Feb 27;48(6):2853–2865. doi: 10.1093/nar/gkaa126

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — SMN2 splicing changes in mouse CNS tissues after SC injection of MOE10-29 or PMO10-29. Splicing analysis of spinal cord (A and B) and brain (C and D) from MOE10-29- and PMO10-29-treated mice by radioactive RT-PCR at three time points (P7, P15 and P30) after treatment as in Figure 1 (n = 4). (*) P < 0.05 high dose versus low dose of the same ASO; (^#) P < 0.05 MOE versus PMO at the same dose.