Table 3.
Univariable and multivariable analysis for performing ALND in cT1-4N+ patients treated with NST
| Number of cases with ALND (%) | Univariable analysis | Multivariable analysis (n = 6442) | |||
|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | ||
| Year of diagnosis | 300/302 (99.3%) in 2006 to 346/652 (53.1%) in 2016 | 0.48 (0.45–0.50) | p < 0.001 | 0.47 (0.45–0.50) | p < 0.001 |
| Age (per year) | 1.01 (0.99–1.01) | p = 0.051 | 1.01 (1.00–1.02) | p = 0.037 | |
| Clinical tumor status | |||||
| T1 | 635/845 (75.1%) | Reference | Reference | ||
| T2 | 2411/2996 (80.5%) | 1.36 (1.14–1.63) | p = 0.001 | 1.32 (1.06–1.63) | p = 0.013 |
| T3 | 1391/1611 (86.3%) | 2.09 (1.69–2.58) | p < 0.001 | 2.00 (1.56–2.58) | p < 0.001 |
| T4 | 1127/1166 (96.7%) | 9.56 (6.70–13.63) | p < 0.001 | 6.49 (4.36–9.66) | p < 0.001 |
| Clinical node status | |||||
| N1 | 4697/5582 (84.1%) | Reference | Reference | ||
| N2 | 220/257 (85.6%) | 1.12 (0.79–1.60) | p = 0.531 | 1.31 (0.87–1.96) | p = 0.197 |
| N3 | 658/759 (86.7%) | 1.23 (0.93–1.53) | p = 0.070 | 1.66 (1.29–2.14) | p < 0.001 |
| ER positive | 0.97 (0.84–1.12) | p = 0.703 | |||
| No | 1831/2157 (84.9%) | ||||
| Yes | 3599/4258 (84.5%) | ||||
| HER2 positive | 0.83 (0.72–0.96) | p = 0.013 | 0.62 (0.52–0.73) | p < 0.001 | |
| No | 3920/4604 (85.1%) | ||||
| Yes | 1532/1851 (82.7%) | ||||
OR odds ratio, CI confidence interval