Fig. 3.

G1T48 inhibits ER-positive breast cancer cell growth. a ER-positive MCF7, b ER-positive BT474 , c ER-positive ZR-75–1 were treated for 7 days with 10^–10 M E2 in addition to ER antagonists (10^–11–10^–5 M). d ER-negative MDA-MB-231 cells were treated for 7 days with ER antagonists (10^–11–10^–5 M). Cellular proliferation was assessed by measuring DNA content (Hoechst stain) and is presented as fold induction over vehicle control. Error bars indicate the SD of triplicate samples