Table 3.
Cox regression analyses predicting DSS in propensity-score-matched cohort.
| Characteristic | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age at diagnosis (years) | 0.999 (0.984-1.014) | 0.874 | ||
| Gender | ||||
| Male | 1 | |||
| Female | 1.182 (0.866-1.615) | 0.292 | ||
| Race | ||||
| White | 1 | |||
| Black | 1.244 (0.782-1.979) | 0.357 | ||
| Other | 0.795 (0.484-1.305) | 0.364 | ||
| Tumor location | ||||
| Rectum | 1 | 1 | ||
| Left colon | 1.302 (0.842-2.013) | 0.236 | 1.012 (0.647-1.584) | 0.957 |
| Right colon | 2.378 (1.513-3.739) | <0.001 | 1.330 (0.839-2.135) | 0.237 |
| Differentiation degree | ||||
| Well/moderately differentiated | 1 | 1 | ||
| Poorly differentiated/undifferentiated | 1.640 (1.168-2.302) | 0.004 | 1.682 (1.184-2.388) | 0.004 |
| Pathological types | ||||
| Adenocarcinoma | 1 | |||
| Mucinous adenocarcinoma/signet-ring cell carcinoma | 1.096 (0.653-1.839) | 0.728 | ||
| Tumor size (cm) | ||||
| <5 | 1 | 1 | ||
| ≥5 | 1.444 (1.055-1.975) | 0.022 | 1.269 (0.919-1.753) | 0.148 |
| T stage | ||||
| T1/T2 | 1 | 1 | ||
| T3/T4 | 4.296 (1.368-13.493) | 0.013 | 1.468 (0.454-4.792) | 0.525 |
| The number of LNMs | ||||
| 0 | 1 | 1 | ||
| 1-3 | 1.114 (0.708-1.753) | 0.641 | 0.726 (0.454-1.160) | 0.181 |
| ≥4 | 2.041 (1.354-3.076) | 0.001 | 1.099 (0.712-1.696) | 0.669 |
| M stage | ||||
| M0 | 1 | 1 | ||
| M1 | 4.677 (3.319-6.590) | <0.001 | 3.343 (2.306-4.847) | <0.001 |
| CEA level (U/ml) | ||||
| <5 | 1 | 1 | ||
| ≥5 | 3.787 (2.504-5.727) | <0.001 | 2.277 (1.444-3.589) | <0.001 |
| PNI status | ||||
| No | 1 | 1 | ||
| Yes | 1.692 (1.239-2.312) | 0.001 | 1.313 (0.951-1.813) | 0.098 |
| TD count | ||||
| 1-3 | 1 | 1 | ||
| ≥4 | 1.641 (1.201-2.243) | 0.002 | 1.820 (1.320-2.509) | <0.001 |
HR: hazard ratio; CI: confidence interval; CEA: carcinoembryonic antigen; PNI: perineural invasion; TD: tumor deposit.