Table 2.
Fold changes of genes that were differentially expressed across either six or five post-exposure time-points in CBNP exposed versus control mice.
| Gene name | Gene symbol | 3 h | 1 d | 2 d | 3 d | 4 d | 5 d | 14 d | 42 d |
|---|---|---|---|---|---|---|---|---|---|
| Common to 6 post-exposure time-points | |||||||||
| CD14 antigen | Cd14 | 1.7 | 1.6 | 2.3 | 1.7 | – | – | 1.8 | 2.4 |
| Chemokine (C–C motif) ligand 12 | Ccl12 | 1.7 | 1.8 | 1.5 | 1.7 | – | – | 1.8 | 1.6 |
| Chemokine (C–C motif) ligand 2 | Ccl2 | 3.3 | 2.0 | 3.0 | 2.1 | – | – | 2.1 | 2.4 |
| Chemokine (C–C motif) ligand 7 | Ccl7 | 3.2 | 2.4 | 3.0 | 2.4 | – | – | 2.4 | 3.0 |
| Chemokine (C–X–C motif) ligand 1 | Cxcl1 | 9.3 | 2.1 | 2.8 | 2.2 | – | – | 3.0 | 2.7 |
| Chemokine (C–X–C motif) ligand 5 | Cxcl5 | 8.2 | 4.2 | 11.7 | 5.2 | – | – | 6.0 | 13.8 |
| Chemokine (C–X–C motif) receptor 1 | Cxcr1 | – | – | 1.9 | 1.6 | 1.8 | 1.5 | 2.3 | 2.7 |
| D site albumin promoter binding protein | Dbp | − 3.6 | 2.9 | − 1.7 | 2.2 | − 1.9 | – | – | − 3.0 |
| Expressed sequence AA467197 | AA467197 | 2.5 | 2.0 | 2.3 | 1.8 | – | – | 3.8 | 4.7 |
| Leukocyte immunoglobulin-like receptor, subfamily B, member 4 | Lilrb4 | 1.6 | 1.8 | 1.7 | 1.5 | – | – | 2.1 | 2.3 |
| Lymphocyte antigen 6 complex, locus F | Ly6f | – | 2.9 | 3.3 | 3.3 | 1.6 | – | 8.0 | 9.0 |
| Serum amyloid A 1 | Saa1 | 3.8 | 6.4 | 3.7 | 2.3 | – | – | 2.2 | 2.4 |
| Serum amyloid A 3 | Saa3 | 7.1 | 30.4 | 12.4 | 8.0 | – | – | 9.7 | 9.1 |
| Common to 5 post-exposure time-points | |||||||||
| Aryl hydrocarbon receptor nuclear translocator-like | Arntl | 1.8 | − 1.6 | – | − 1.6 | 1.6 | – | – | 1.7 |
| Brevican | Bcan | – | − 1.7 | − 1.6 | − 1.5 | – | – | − 1.6 | − 2.1 |
| Cholesterol 25-hydroxylase | Ch25h | 4.0 | 1.6 | – | 1.7 | – | – | 2.9 | 2.7 |
| Colony stimulating factor 2 (granulocyte-macrophage) | Csf2 | 1.6 | 2.2 | – | 1.8 | – | – | 1.7 | 1.6 |
| Chemokine (C–X–C motif) ligand 10 | Cxcl10 | 3.9 | 2.3 | 2.1 | – | – | 1.7 | – | 1.9 |
| Glutathione S-transferase, alpha 2 (Yc2) | Gsta2 | – | − 1.8 | − 1.6 | – | − 1.5 | – | − 1.5 | − 1.6 |
| Interleukin 33 | Il33 | − 1.7 | 1.6 | 2.0 | 1.7 | – | – | – | 1.7 |
| Lipocalin 2 | Lcn2 | – | 3.1 | 2.9 | 2.5 | – | – | 3.3 | 3.5 |
| Lymphocyte antigen 6 complex, locus I | Ly6i | – | 2.8 | 3.2 | 3.2 | – | – | 8.0 | 9.3 |
| NADPH oxidase activator 1 | Noxa1 | – | 1.8 | 1.8 | 1.6 | – | – | 3.3 | 2.0 |
| NADPH oxidase organizer 1 | Noxo1 | – | 2.2 | 2.6 | 2.7 | – | – | 3.8 | 3.9 |
| Orosomucoid 2 | Orm2 | – | 3.7 | 1.7 | 1.6 | – | – | 3.0 | 1.7 |
| Polymeric immunoglobulin receptor | Pigr | – | 1.9 | 2.2 | 2.4 | – | – | 2.4 | 2.8 |
| STEAP family member 4 | Steap4 | 1.7 | 1.7 | – | 1.5 | – | – | 1.9 | 2.1 |
| Tissue inhibitor of metalloproteinase 1 | Timp1 | 2.6 | 3.8 | 3.1 | 2.1 | – | – | 1.7 | – |
| WAP four-disulfide core domain 17 | Wfdc17 | – | 2.4 | – | 1.9 | 1.7 | – | 4.0 | 5.1 |
All genes had a p < 0.05; “–” indicates that gene in that specific time-point did not pass the selection criteria. h — hour; d — day.