GROUP/DIS.	METHOD	FEATURES include in the model	SENS	SPEC	ACCUR	KAPPA
Combined	LDA	Age at dx, GI infections, lymphadenitis, “no infection site”, allergy, leukopenia, low IgM	100%	91%	91%	0.9
Antibody	LDA	Age at dx, lymphadenitis, “no infect. site”. Gram negative isolate, leukopenia, low IgG and low IgA.	78.4%	94.6%	88.8%	0.75
Well-defined	LDA	current age, age at dx, lymphadenitis, fungi, lymphopenia, eosinophilia, thrombocytopenia, and low IgG.	82.9%	78.1%	79.5%	0.55
Immune disregulation	LDA	“no infect. site”, susceptibility to virus, lymphopenia	50%	93.6%	92%	0.28
Phagocyte	MLR	Sex, age, consanguinity, lung infect., urinary tract infect., allergy, low IgA, high IgA, cellulitis/osteomyelitis, “no infect. site”. mycobacterial susceptibility, fungi susceptibility mycobacterial isolate, neutropenia, eosinophilia, thrombocytopenia.	90%	99.1%	97.2%	0.914
XLA	LDA	Sex, low IgG. low IgM, protozoo isolate, Gram negative isolate.	91.7%	86%	86.9%	0.62
CVID	LDA	Age at Dx, low IgG.	84.6%	81.2%	81.5%	0.37
AT	LDA	“no infect. site”, autoimmunity, cancer, anemia, neutropenia, lymphopenia, low IgG, low IgM, low IgA.	82.6%	95%	93.1%	0.75
CGD	MLR	Lung infection, urinary tract infect. lymphadenitis, cellulitis/osteomielitis, allergy, neutropenia, eosinophilia, thrombocytopenia, low IgG, low IgA	90%	90.3%	90.3%	0.66