Fig. 5.

This figure shows the EpiMatrix immunogenicity scale to prospectively predict clinical immunogenicity. It compares novel protein sequences to proteins of known varying immunogenic potential. The new protein therapeutic GDNF was about to be used as treatment for Parkinson's disease or amyotrophic lateral sclerosis (ALS). In EpiMatrix analysis, however, it scores as high as published highly immunogenic peptides from influenza hemagglutinin and tetanus toxin. This might be the cause for the observed side effects during its clinical use as therapeutic.