Table 1.

Nucleotide differences between AH65-E and AH65-R and mutations in AH65-E-TC and AH65-R-TC after tissue culture passage^a

^aThe four genomic sequences were aligned with ClustalW program in Lasergene software (DNASTAR Inc). Uniform length of 30,894 nt was achieved after trimming sequence ends. ^bPositions for nucleotide changes in individual genes are shown. ^cNucleotides are in bold italics and boxed when AH65-E mutated to nucleotides identical to AH65-R after tissue culture passage. ^dThe ambiguous nucleotides are in bold italics and underlined.