Fig. 2.

Administration of Dox allows dose-dependent expression of EPO in the retina over 5 years after subretinal delivery of AAV2/5.CAG.TetOn.epo in macaque. Intravenous administration of Dox was performed by a 3-day Dox pulse (Dox-ratiopharm SF, Ratiopharm) and oral administration consisted of the daily uptake (3 days) of Dox hidden in dry fruits. Numbers above the peaks indicate the dose of Dox administered in mg/kg. Continuous graphs indicate intravenous administration of Dox and dotted graphs indicate oral administration of Dox. The horizontal dashed grey line indicates average peak EPO levels of the first 4 inductions by 10 mg/kg.