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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Gastroenterology. 2019 Dec 19;158(5):1274–1286.e12. doi: 10.1053/j.gastro.2019.12.012

Table 3:

Risk estimates for early-onset versus late-onset CRC associated with a 95-SNP PRS among participants with and without Lynch Syndrome, in the Ohio cohorta

PRS per 1 SD N (cases) N (controls) OR (95% CI) P value P value for interactionb
Including Lynch and Non-Lynch Cases

All Subjects 0.0369
 <50 Years-Old 574 979 1.73 (1.54, 1.95) 1.39E-19
 ≥50 Years-Old 2525 1463 1.47 (1.37, 1.58) 1.77E-28
Negative Family History 0.0106
 <50 Years-Old 449 931 1.81 (1.59, 2.07) 9.64E-19
 ≥50 Years-Old 1885 1271 1.45 (1.34, 1.56) 1.16E-21
Positive Family History 0.1517
 <50 Years-Old 106 48 1.28 (0.84, 1.97) 0.2530
 ≥50 Years-Old 565 192 1.55 (1.30, 1.84) 1.12E-06

Excluding Lynch Cases

All Subjects 0.0149
 <50 Years-Old 537 979 1.82 (1.61, 2.06) 2.63E-21
 ≥50 Years-Old 2471 1463 1.49 (1.39, 1.60) 1.11E-29
Negative Family History 0.0107
 <50 Years-Old 438 931 1.83 (1.60, 2.09) 7.50E-19
 ≥50 Years-Old 1856 1271 1.46 (1.35, 1.57) 4.30E-22
Positive Family History 0.5627
 <50 Years-Old 80 48 1.53 (0.98, 2.41) 0.0635
 ≥50 Years-Old 540 192 1.61 (1.34, 1.92) 2.34E-07
a

The logistic regression models include age, sex, principal components, and polygenic risk score.

b

P value produced from interaction term with continuous PRS (per SD) and age (<50 versus ≥50 years).