Table 3:
Risk estimates for early-onset versus late-onset CRC associated with a 95-SNP PRS among participants with and without Lynch Syndrome, in the Ohio cohorta
PRS per 1 SD | N (cases) | N (controls) | OR (95% CI) | P value | P value for interactionb |
---|---|---|---|---|---|
Including Lynch and Non-Lynch Cases | |||||
All Subjects | 0.0369 | ||||
<50 Years-Old | 574 | 979 | 1.73 (1.54, 1.95) | 1.39E-19 | |
≥50 Years-Old | 2525 | 1463 | 1.47 (1.37, 1.58) | 1.77E-28 | |
Negative Family History | 0.0106 | ||||
<50 Years-Old | 449 | 931 | 1.81 (1.59, 2.07) | 9.64E-19 | |
≥50 Years-Old | 1885 | 1271 | 1.45 (1.34, 1.56) | 1.16E-21 | |
Positive Family History | 0.1517 | ||||
<50 Years-Old | 106 | 48 | 1.28 (0.84, 1.97) | 0.2530 | |
≥50 Years-Old | 565 | 192 | 1.55 (1.30, 1.84) | 1.12E-06 | |
Excluding Lynch Cases | |||||
All Subjects | 0.0149 | ||||
<50 Years-Old | 537 | 979 | 1.82 (1.61, 2.06) | 2.63E-21 | |
≥50 Years-Old | 2471 | 1463 | 1.49 (1.39, 1.60) | 1.11E-29 | |
Negative Family History | 0.0107 | ||||
<50 Years-Old | 438 | 931 | 1.83 (1.60, 2.09) | 7.50E-19 | |
≥50 Years-Old | 1856 | 1271 | 1.46 (1.35, 1.57) | 4.30E-22 | |
Positive Family History | 0.5627 | ||||
<50 Years-Old | 80 | 48 | 1.53 (0.98, 2.41) | 0.0635 | |
≥50 Years-Old | 540 | 192 | 1.61 (1.34, 1.92) | 2.34E-07 |
The logistic regression models include age, sex, principal components, and polygenic risk score.
P value produced from interaction term with continuous PRS (per SD) and age (<50 versus ≥50 years).