Table 1 –
Relationship between Detection Of Gluten Ingestion or Excretion and Measures of Dietary Adherence and Celiac Disease Activity at 24 months from diagnosis
| Gluten detectedd (N =12) | No gluten detected (N=6) | |
|---|---|---|
| [N (%)] | [N (%)] | |
| Celiac Symptom Index (CSI)a | ||
| ≤30 | 7(58%) | 3 (50%) |
| 31–40 | 5 (42%) | 3 (50%) |
| Gluten-Free Eating Assessment Tool short (GF-EATs)b | ||
| Frequent gluten (>1/week) | -- | -- |
| Occasional gluten (1–4 times per month) | 1 (8%) | -- |
| Rare intentional gluten ingestion (<1/month) | 1 (8%) | -- |
| Rare accidental gluten ingestion (<1/month) | 9 (76%) | 5 (83%) |
| No gluten | 1 (8%) | 1 (17%) |
| Celiac Diet Adherence Test (CDAT)c | ||
| < 13 | 10 (83%) | 4 (66%) |
| 13–14 | 2 (17%) | 2 (33%) |
| TTG IgA multiples of upper limit of normal | ||
| <1 | 7 (58%) | 4 (66%) |
| ≥1 | 5 (42%) | 2 (33%) |
| ≥2 | 3 (25%) | -- |
| Marsh Classification | ||
| Marsh 0 | 4 (33%) | 2 (33%) |
| Marsh 1 | -- | 2 (33%) |
| Marsh 3a | 8 (66%) | 2 (33%) |
| Marsh 3b | -- | -- |
| Marsh 3c | -- | -- |
Lower scores more desirable, 16 items with possible range 16 to 80, scores ≤30 suggestive of clinical remission, scores ≥45 suggestive of ongoing active celiac disease. Leffler DA, Dennis M, Edwards-George JB et al. A Validated Disease-Specific Symptom Index for Adults with Celiac Disease. Clin Gastroenterol Hepatol 2009;7(12), 1328–34.
See supplementary file for full instrument.
Lower scores more desirable, 7 items with possible range 7–35, scores ≥13 predict inadequate GFD adherence. Leffler DA, Dennis M, Edwards-George JB et al. A simple validated gluten-free diet adherence survey for adults with celiac disease. Clin Gastroenterol Hepatol 2009;7(5), 530–6.
Limit of detection: 1.6 ppm gluten in food; 160 ng GIP per gram stool; 2.2 ng GIP per ml urine.