Table 3:
Multivariable Cox proportional hazards models of risk factors for posttransplant donor-specific HLA antibody (DSA) development
| Variable | Non-stratified | Stratified for CPB | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Pseudomonas isolation post-LTx | 1.75 | 1.18-2.60 | 0.005 | 1.76 | 1.19-2.61 | 0.005 |
| Pre-transplant CPRA | 1.01 | 1.00-1.01 | 0.009 | 1.008 | 1.00-1.01 | 0.008 |
| PGD grade 3 at any point | 1.25 | 0.91-1.71 | 0.176 | 1.173 | 0.85-1.62 | 0.331 |
| LAS | 1.00 | 1.00-1.01 | 0.397 | 1.00 | 0.99-1.01 | 0.879 |
| Variable | Non-stratified | Stratified for CPB | ||||
| HR | 95% CI | p | HR | 95% CI | p | |
| Acute rejection Grade ≥ A2* | 2.06 | 1.43-2.97 | <0.001 | 2.01 | 1.4-2.9 | <0.001 |
| Pre-transplant CPRA | 1.01 | 1.00-1.01 | 0.017 | 1.01 | 1.00-1.01 | 0.015 |
| PGD grade 3 at any point | 1.27 | 0.92-1.75 | 0.141 | 1.2 | 0.87-1.65 | 0.276 |
| LAS | 1.00 | 1.00-1.01 | 0.430 | 1.00 | 0.99-1.01 | 0.927 |
| Variable | Non-stratified | Stratified for CPB | ||||
| HR | 95% CI | p | HR | 95% CI | p | |
| Lymphocytic bronchiolitis Grade ≥ B1R* | 1.72 | 1.18-2.51 | 0.005 | 1.72 | 1.18-2.51 | 0.005 |
| Pre-transplant CPRA | 1.01 | 1.00-1.01 | 0.012 | 1.01 | 1.00-1.01 | 0.01 |
| PGD grade 3 at any point | 1.3 | 0.94-1.78 | 1.109 | 1.21 | 0.88-1.68 | 0.238 |
| LAS | 1.00 | 1.00-1.01 | 0.389 | 1.00 | 0.99-1.01 | 0.876 |
Abbreviations: CPRA: calculated panel reactive antibodies; CPB: cardiopulmonary bypass; HR: hazards ratio; CI: confidence interval; LAS: lung allocation score; LTx: lung transplant; PGD: primary graft dysfunction.