Table 4:
Univariable Cox proportional hazards models of risk factors for posttransplant donor-specific HLA antibody (DSA) development restricted to DQ-DSA
| Variable | HR | 95% CI | p |
|---|---|---|---|
| Recipient age | 0.98 | 0.97-0.99 | 0.001 |
| Diagnosis, CF | 1.04 | 0.94-1.14 | 0.49 |
| LAS | 1.00 | 0.99-1.01 | 0.93 |
| Pre-transplant CPRA | 1.00 | 0.99-1.01 | 0.81 |
| Transplant type, bilateral | 0.64 | 0.28-1.45 | 0.28 |
| Intraoperative CPB | 1.32 | 0.95-1.83 | 0.1 |
| Induction, Basiliximab | 0.66 | 0.46-0.94 | 0.02 |
| PGD grade 3 at any time | 1.08 | 0.74-1.56 | 0.70 |
| Acute rejection Grade ≥ A2* | 2.05 | 1.38-3.05 | <0.001 |
| Lymphocytic bronchiolitis Grade ≥ B1R* | 2.07 | 1.39-3.08 | <0.001 |
| Cumulative A rejection score post-LTx | 1.11 | 1.04-1.18 | 0.001 |
| Cumulative B rejection score post-LTx | 1.17 | 1.07-1.29 | 0.001 |
| Gram-positive bacteria isolation post-LTx* | 0.99 | 0.62-1.58 | 0.95 |
| Gram-negative bacteria isolation post-LTx* | 1.41 | 0.98-2.02 | 0.06 |
| Pseudomonas isolation post-LTx* | 2.16 | 1.43-3.26 | <0.001 |
| Number of positive Pseudomonas cultures | 1.11 | 1.06-1.16 | <0.001 |
| Pseudomonas isolation pre-LTx | 1.17 | 0.78-1.77 | 0.44 |
| Aspergillus isolation post-LTx* | 1.38 | 0.84-2.26 | 0.20 |
| CMV in blood post-LTx* | 0.77 | 0.52-1.14 | 0.19 |
| CMV in BAL post-LTx* | 0.83 | 0.53-1.30 | 0.42 |
Abbreviations: BAL: bronchoalveolar lavage; CF: cystic fibrosis; CPRA: calculated panel reactive antibodies; CPB: cardiopulmonary bypass; CMV: cytomegalovirus; LTx: lung transplant; PGD: primary graft dysfunction. p value is for Cox proportional hazards model with “time to DSA positivity” as time to event.
*
indicates variables which were evaluated using a time-dependent Cox proportional hazards model.