Table 2. Summary of changes in pro-inflammatory and anti-inflammatory cytokines expression in different treatment groups at 10 weeks post-MI.
CSF, colony stimulating factor; IL, interleukin
| Cytokines (pg/ml) | |||||||
|---|---|---|---|---|---|---|---|
| Groups | Erythopoietin | Granulocyte CSF | Glucagon-like Peptide-1 | Granulocyte-Macrophage-CSF | Keratinocyte Chemoattractant | Interferon-gamma | IL-1 alpha |
| Sham | 584.15 (205.75, 673.11) |
17.62±14.29 | 933.25 (576.8, 3932.6) |
107.15 (56.32, 151.1) |
97.36 (51.1, 169.98) |
70.715 (41.32, 117.44) |
107.93±81.25 |
| Saline | 736.2 (653.5, 912.9)★ |
46.29±18.59★ | 3426.05 (2983.4, 4562.3)★ |
619.85 (402.3, 780.3)★ |
315.3 (156.4, 567.4)★ |
299.7 (177.3, 388.9)★ |
192.30±94.64 |
| AAV9/null | 551.15 (407.9, 578.5)§ |
29.80±30.35 | 1698 (657, 3425) |
334.4 (275.8, 432)★ |
153.65 (86.7, 234.5)§ |
260.25 (67.9, 326.5)★ |
211.60±165.46 |
| SS | 954.71 (828.13, 1072.52)★□ |
34.78±27.38 | 4607.65 (3456, 4923.6)★□ |
212.7 (152.9, 288.2)§ |
122.2 (45.25, 189.2)§ |
159.11 (102.5, 257.92)★§ |
237.18±161.98 |
| 481.58 (383.82, 856.66)¶ |
21.31±14.98 | 609.45 (570.7, 938.6)§¶ |
103.185 (47.39, 434.4)§□ |
50.12 (21.07, 132.5)§□ |
77.37 (52.79, 165.9)§□ |
134.76±115.68 | |
| IL-1 beta | IL-2 | IL-4 | IL-5 | IL-6 | IL-7 | IL-10 | IL-12 | |
|---|---|---|---|---|---|---|---|---|
| Sham | 118.9 (85.75,142.2) |
333.83±183.14 | 64.525 (25.7, 84.9) |
200.76 (124.34, 217.8) |
47.63 (35.3, 62.2) |
272.225 (322.9, 174.83) |
605.95 (330.3, 801.2) |
79.91±58.76 |
| Saline | 382.8 (238.4, 603.4)★ |
340.89±156.16 | 158.85 (143.5, 187.6)★ |
287.9 (244.3, 382.1) |
122.2 (67.7, 188.3)★ |
274.8 (208.4, 377.4) |
789 (566.5, 923.4) |
184.76±83.70 |
| AAV9/null | 361.1 (219.4, 473.8)★ |
415.69±293.55 | 113.95 (67.5, 145.4)★ |
250 (200.3, 443.5) |
47.25 (43.7, 106.9) |
195.3 (78.5, 342.2) |
570.8 (438.9, 946.8) |
156.91±104.57 |
| SS | 172.14 (103.69, 474.8) |
399.06±207.01 | 82.855 (33.71, 156.8)§ |
253.85 (201.9, 288.2) |
91.95 (34.46, 135.7) |
321.615 (83.54, 583.9) |
658.235 (395.2, 1023) |
272.55±268.29 |
| SC | 160.935 (68.06, 244.67)§ |
441.57±460.77 | 48.445 (34.33, 89.77)§□ |
152.415 (108.76, 275.9) |
62.5 (38.3, 159.8) |
120.965 (9.9, 259.8)§ |
344.45 (294, 731.24) §¶ |
139.86±142.76 |
| IL-13 | IL-17 | IL-18 | Macrophage-CSF | Monocyte Chemoattractant Protein-1 | Macrophage Inflammatory Protein-3 | Chemokine ligand (RANTES) | Tumor Necrosis Factor-alpha | |
| Sham | 85.25 (77.3, 117.4) |
61.02 (29.9, 107.47) |
2997.87±1712.14 | 237.35±58.93 | 725.12±179.54 | 54.945 (40.77, 72.9) |
329.6±39.7 | 256.9±43.0 |
| Saline | 172 (102.3, 236.7)★ |
143.1 (78.4, 203.4)★ |
4024.00±2126.39 | 219.35±97.12 | 1641.84± 875.7★ | 160.3 (129.7, 255.6)★ |
340.9±52.9 | 272.5±40.1 |
| AAV9/null | 102.4 (83.4, 143.5) |
93.5 (43.6, 145.3) |
3571.90±2552.83 | 209.14±130.96 | 966.77±874.71 | 96.7 (56.8, 187.5)★ |
279.7±60.3 | 113.4±33.7 |
| SS | 100.8 (49.7, 164.3) |
70.7 (55.58, 129.9) |
6916.78±4362.81★ | 270.07±69.21 | 851.22±261.92§ | 80.625 (44.49, 113.57)§ |
294.1±43.3 | 215.7±50.8 |
| SC | 63.9 (29.9, 106.9)§□ |
56.575 (32.94, 134.5)§ |
3820.35±2266.95 | 284.64±38.78 | 845.27±177.46§ | 59.985 (34.13, 146.23)§ |
240.6±31.8 | 128.7±22.4 |
★
P <0.05 versus sham
§
P<0.05 versus saline
□
P<0.05 versus null
¶
P<0.05 versus ss