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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Retina. 2020 Apr;40(4):618–631. doi: 10.1097/IAE.0000000000002657

Figure 5. Transition from subretinal drusenoid deposits to outer retinal atrophy.

Figure 5.

INL, inner nuclear layer; OPL, outer plexiform layer; HFL, Henle fiber layer; ONL, outer nuclear layer; IS, inner segment; OS, outer segment; RPE, retinal pigment epithelium; BrM, Bruch membrane; BLamD, basal laminar deposit; Green arrowheads, ELM, external limiting membrane; Red arrowheads, SDD, subretinal drusenoid deposits. A. 2300 μm nasal. From left to right (less affected to more affected) SDD diminish in size in association with photoreceptor OS displacement, IS shortening and ONL thinning. Thickness of RPE and BLamD varies little across this area. The area with SDD gradually transitions to an area lacking SDD and photoreceptor OS and IS are short. Further to the right, gaps in the ONL due to photoreceptor loss are filled with pale-staining hypertrophic Müller cells (purple arrowhead). The RPE is relatively intact over continuous BLamD which thickens and includes basal mounds. At the right is local RPE atrophy (yellow arrowhead) with persistent BLamD, shedding of RPE granule aggregates (orange arrowhead) into the basal mound, and slight upward deflection of the ELM (teal arrowhead). Eighty-five-year-old woman.