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. 2019 Mar 6;28(5):607–618. doi: 10.1177/0963689719835181

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 3. — Examination of the changes in microglia/macrophages and autophagy in optic nerves after PONT. (A) Effects of PONT on the activation of microglia/macrophages. Western blot analysis shows that the expression level of CD68 increases significantly 1 week after PONT in the injured optic nerves (student t-test, ***p < 0.001), but there was no significant difference between optic nerves from rats 4 weeks after PONT and that of normal retinas (student t-test, p > 0.05). (B) Effects of PONT on the polarization of microglia/macrophages. The expression levels of iNOS and Arginase-1 increase significantly 1 week after PONT (Student t-test, **p < 0.01); but not 4 weeks after PONT (Student t-test, p > 0.05). (C) Activation of autophagy after PONT. The LC3 II expression increased significantly 1 week after PONT (Student t-test, *p < 0.05); but not 4 weeks after PONT (Student t-test, p > 0.05). (mean ± SEM; NS: not significant; n = 6 in each group for Western blot analysis, two optic nerves in one sample.).