Fig. 4.
Effects of Lycium barbarum polysaccharides (LBP) on RGC survival 1 week and 4 weeks after PONT. (A) Both in temporal and nasal retinal halves, LBP treatment did not delay the degeneration of RGCs 1 week after PONT (Student's t-test; p > 0.05). However, LBP reduced the degeneration of RGCs in the nasal retinas 4 weeks after PONT (Student's t-test, *p < 0.05,); but not in the temporal retinas (Student's t-test; p > 0.05). (B–I) The photographs of RGCs labeled with Fluoro-Gold (FG) in both the temporal and nasal retinas are about 1.5 mm away from the optic disc: (B–E) In the temporal retinas, the densities of RGCs were similar between the PBS and LBP groups both 1 week and 4 weeks after PONT (Student's t-test, p > 0.05). (F–I) In the nasal retinas, the density of RGCs in the LBP group was higher than that in the PBS group 4 weeks after PONT (Student's t-test, *p < 0.05); but not 1 week after PONT (Student's t-test; p > 0.05). (Mean ± SEM; NS: not significant; n = 9 in both PBS and LBP groups both 1 week and 4 weeks after PONT).