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. 2019 Jun 4;25(6):374–388. doi: 10.1177/1753425919853333

Table 4.

Phagocytosis and oxidative-burst activity of immune cells after endotoxin and trimodulin treatment.

Trimodulin (mg/ml) Phagocytosisa,b
Oxidative bursta,c
24 h LTA+1 h trimodulin (pHrodo-conjugated E. coli)
24 h LPS+1 h trimodulin (FITC-labelled E. coli)
Reactive oxidant-positive monocytes
Enzymatic activity
LTA (µg/ml) % of cells (n=3)d LPS (ng/ml) % of cells (n=7) LPS (ng/ml) % of cells (n=5) Monocytes (n=5) Granulocytes (n=5)
0 0 7.7 ± 2.1 0 92.0 ± 4.8 0 45.9 ± 14.6 2.3 ± 1.4 3.8 ± 1.5
0.5 0 7.5 ± 2.3 0 91.6 ± 5.4 0 n.d. n.d. n.d.
5 0 6.5 ± 3.0 0 90.8 ± 4.6 0 65.0 ± 11.6 3.1 ± 1.2 7.3 ± 1.7*
0 1 7.0 ± 2.0 0.05 88.5 ± 6.2 0.05 56.2 ± 9.4 2.6 ± 1.3 5.3 ± 0.7
0.5 1 7.3 ± 2.2 0.05 89.8 ± 7.5 0.05 n.d. n.d. n.d.
5 1 6.6 ± 2.9 0.05 88.0 ± 7.4 0.05 60.2 ± 10.5 3.5 ± 1.1 6.6 ± 0.7
0 10 7.6 ± 1.2 0.5 91.0 ± 9.3 0.5 63.6 ± 12.4 2.8 ± 1.3 5.4 ± 1.1
0.5 10 7.7 ± 1.1 0.5 91.3 ± 9.5 0.5 n.d. n.d. n.d.
5 10 7.0 ± 1.8 0.5 91.6 ± 6.8 0.5 70.8 ± 10.6 3.8 ± 1.7 7.5 ± 2.1
a

Activities measured in whole blood samples.

b

Phagocytosis measured according to Figure 4a.

c

Oxidative burst after 24 h of LPS stimulation of whole blood and 1 h of trimodulin treatment (Figure 4c).

d

Mean and SD values obtained from a number (n) of donors as indicated.

*One condition comparison between untreated and trimodulin-treated cells resulted in P ≤ 0.05 (t-test). All data are mean (SD) unless otherwise specified.

n.d.: not determined.