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. 2020 Jan 17;9(4):531–542. doi: 10.1002/sctm.19-0199

Figure 5.

Figure 5

Valproic acid (VPA)‐treated grafts maintain long‐term multilineage human cell chimerism in vivo. A,B, Human CD45 cell engraftment in the marrows of NSG mice harvested at 16 weeks post‐transplantation with grafts from PCs, VPA and control cultures, initiated from mobilized peripheral blood (mPB; n = 7, panel A) and adult bone marrow (ABM; n = 9, panel B). Note: six of nine mice transplanted with grafts from control ABM cultures did not show any human cell chimerism, and hence cannot be displayed on a logarithmic scale. C‐E, Lineage analysis of the long‐term engrafting human cells in the marrows (n = 7, panel C) and spleens (n = 5, panel D) of mice transplanted with mPB‐derived grafts, and in the marrows of mice transplanted with ABM‐derived grafts (n = 9, panel E). Error bars represent SD; *P < .05; ***P < .001