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. 2020 Mar 20;11:408. doi: 10.3389/fimmu.2020.00408

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Copyright © 2020 Abdelhamid, Cabana-Puig, Swartwout, Lee, Li, Sun, Li, Ross, Cecere, LeRoith, Werre, Wang, Reilly and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunosuppressive functions of tRA post-treatment in pristane-induced lupus. (A) Serum levels of anti-dsDNA IgG antibodies and their ratios to total IgG antibodies at 6 months post pristane injection as determined with ELISA. (B) Correlation between autoantibody levels and glomerular pathological scores as determined with Spearman correlation analysis. (C) IgG deposition in the kidney as determined with immunohistochemical staining using an anti-IgG monoclonal antibody (green) and DAPI (blue). Red arrows indicate IgG deposition. (D–F) Renal transcript levels of Tnfα (D), Ccl3/Mip1 (E), and Itgal subunit of LFA1 (F) as determined with RT-qPCR. (G) Correlation between renal Itgal expression and glomerular pathological scores. Significant differences were shown as *p < 0.05, **p < 0.01.