Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 18;7:40. doi: 10.3389/fmolb.2020.00040

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Glass, Duncan and Biggin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Orientations of the β1/3 subunit on the membrane. (A) The Na_v β1 subunit complex, highlighting the orientation, and interaction of the β1 subunit with respect to the membrane [PDB: 6AGF (Pan et al., 2018)]. (B) Structure of the trimeric Ig domain from β3 [PDB: 4L1D (Namadurai et al., 2014)]. (C) Overlay of the trimeric β3 Ig domain on the Ig domain of the β1 subunit, demonstrating the anticipated position of the β1 TMD and suggesting that these conformations are not compatible. The approximate location of the membrane is indicated by a gray box and dotted lines.