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Co-expression (cc > 0.8) of IFNγ with six ICPs in CRC. (A) IFNγ and all six ICPs co-expressed with CD8A/CD8B/CD4 within one 190 gene network in 32 IFNγ positive CRCs. (B) Tim3 and PDL1 co-expressed with CD4 within one 83 gene network in 47 IFNγ negative CRCs. (C) CTLA4 co-expressed with PD1 within one 88 gene expression network, but not Tim3, in normal colon without CD8/CD4.
