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. 2020 Mar 19;11:224. doi: 10.3389/fimmu.2020.00224

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Copyright © 2020 Xu, Pelosof, Wang, McFarland, Wu, Phue, Lee, Shen, Juhl, Wu, Alterovitz, Petricon and Rosenberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Close association of IFNγ with T cells in tumor but not in normal tissues. (A) Box and Whisker plot of immune cell genes in IFNγ positive CRCs. Upregulation (P < 0.05) of T cells (CD8A, 3.5-fold; CD3E, 2.0-fold; CD4, 1.3-fold; FOXP3, 1.5-fold) but not B cell (CD19) (1.2-fold, P = 0.38), neutrophil (CD11b) (1.4-fold, P = 0.079), M1 (ARG1) (0.68-fold, P = 0.62), (ARG2) (1.0-fold, P = 0.87), or M2 (ARG2, CCR7) (1.2-fold, P = 0.30) leukocyte-related genes in IFNγ positive CRC vs. negative CRC. (B) Box and Whisker plot of immune cell genes in normal colon tissue. No upregulation (P > 0.05) of T cells (CD8A, 0.93-fold; CD3E, 1.0-fold; CD4, 1.0-fold; FOXP3, 1.1-fold), B cell (CD19) (1.4-fold), neutrophil (CD11b) (1.1-fold), MDSC1 (ARG1) (1.0-fold), (ARG2) (0.97-fold), or MDSC2 (ARG2, CCR7) (1.2-fold) leukocytes related genes in tissues adjacent to IFNγ positive and negative CRCs.