Table 3.

List of all direct comparative studies of the major FDA-approved multiplex respiratory assays.

Study	Comparison	Cohen’s Kappa, κ (95% CI)	Interpretation of κ [33,35]
Lee et al. (2017) [36]	Luminex NxTAG RPP: Luminex xTAG RVPv2	0.85 (0.757–0.932)	Strong
Chen et al. (2016) [37]	Luminex NxTAG RPP: FilmArray RP	0.92 (0.90–0.94)	Almost perfect
Hwang et al. (2014) [38]	xTAG RVP: Nanosphere RV+	0.908a	Almost perfect
Popowitch, et al. (2013) [34]	FilmArray RP: eSensor RVP: Luminex xTAG RVPv1: Luminex xTAG RVP	Not reported	n/a
Babady et al. (2012) [21]	Luminex xTAG RVP: FilmArray RP	0.685b	Moderate
Rand et al. (2011) [49]	FilmArray RP: Luminex xTAG RVP	0.91 (0.85–0.97)	Almost perfect
Pabbaraju et al. (2011) [39]	Luminex xTAG RVP: Luminex xTAG RVP FAST	0.548–1.00c	Weak to almost perfect

^aStudy only included comparison of RSV, influenza A and B.

^bNo 95% CI reported.

^cCalculated κ for all targets individually. Low end kappa coefficient is for influenza B only.