Table 2.

Relative changes in ¹⁸F-FDG PET/CT and DW-MRI parameters between pathologic complete response (TRG 1) and non-pathologic complete response (TRG 2–4), as well as between good response (TRG 1–2) and poor response (TRG 3–4).

		Median (IQR)		p-value*	Benjamini-Hochberg adjusted p-value	c-statistic
		pCR (TRG 1) (n=18)	non-pCR (TRG 2–4) (n=51)
During treatment	ΔSUVmean (%)	−27 (−38, −6)	−19 (−33, −3)	0.246	0.264	0.59
	ΔSUVmax (%)	−29 (−46, −8)	−23 (−35, −2)	0.408	0.408	0.57
	ΔTLGduring (%)	−54 (−64, −23)	−20 (−50, 10)	0.020	0.052	0.69
	ΔADCduring(%)	28 (15, 39)	11 (4, 17)	0.001	0.008	0.77
Post treatment	ΔSUVmean (%)	−63 (−68, −49)	−42 (−58, −16)	0.003	0.016	0.74
	ΔSUVmax (%)	−68 (−78, −58)	−54 (−71, −31)	0.026	0.052	0.68
	ΔTLGpost (%)	−86 (−93, −81)	−65 (−88, −32)	0.006	0.024	0.72
	ΔADCpost (%)	34 (13, 46)	20 (10, 38)	0.139	0.201	0.63
		Median (IQR)		p-value*	Benjamini-Hochberg adjusted p-value	c-statistic
		GR (TRG 1–2) (n=43)	non-GR (TRG 3–4) (n=26)
During treatment	ΔSUVmean (%)	−26 (−42, −5)	−19 (−27, −2)	0.054	0.086	0.64
	ΔSUVmax (%)	−31 (−44, −14)	−12 (−29, 2)	0.016	0.051	0.67
	ΔTLGduring (%)	−37 (−62, −9)	−17 (−38, 20)	0.024	0.052	0.66
	ΔADCduring (%)	20 (13, 33)	7.3 (0, 11)	<0.001	0.008	0.84
Post treatment	ΔSUVmean (%)	−51 (−66, −34)	−42 (−56, −11)	0.042	0.075	0.65
	ΔSUVmax (%)	−63 (−76, −44)	−53 (−74, −26)	0.187	0.230	0.60
	ΔTLGpost (%)	−81 (−89, −54)	−64 (−88, −35)	0.248	0.264	0.59
	ΔADCpost (%)	24 (13, 44)	21 (6, 30)	0.151	0.201	0.61

^*p-value calculated based on Mann-Whitney U test

ADC apparent diffusion coefficient; c-statistic concordance statistic; GR good response; IQR interquartile range; pCR pathologic complete response; SD standard deviation; SUV standardized uptake value; TLG tumor lesion glycolysis; TRG tumor regression grade