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. 2020 Apr;479:112764. doi: 10.1016/j.jim.2020.112764

Fig. 2.

Fig. 2

Tier 1 screening assay cut point determination. A. Tier 1 screening assay signal over baseline (S/B) observed for repeated (N = 6) measurements of individual serum (IS) samples (N ≥ 99) and pooled HIV- human sera (PS) from drug naïve subjects for each of the indicated bnAbs. For each bnAb, data points defined as outliers based on quartile three plus 1.5× the interquartile range are indicated in color. Inset values indicate the rate of Tier 1 screening assay positivity observed among this set of individual and pooled sera from drug naïve subjects. B. S/B responses observed across repeated screening assay runs (N = 6) for 3BNC117 (N = 129, each dot represents the mean of technical duplicates). Dotted line represents the screening assay cut point. Data points defined as Tier 1 positive are indicated in color. Bar and whiskers represent median with interquartile range).