Fig. 5.

Free drug tolerance. The ability of free drug to reduce S/B signal was evaluated at high (500 ng/mL) and low (100 ng/mL for all bnAbs except PGT121 which was run at 200 ng/mL) levels of anti-id. Dotted lines indicate the screening assay positivity cut point. Bar and whiskers indicate standard error of the mean. Tabulated values indicate the maximum tested concentration of free drug that could be added to high and low levels of anti-id without resulting in a false negative response call.