Table 4.
Different proteins cleaved from the 1ab protein of TW2575/98
| Proteinsa | Amino acid Positions (residue) | Cleavage siteb | Cleavage enzyme |
|---|---|---|---|
| Leader protein P87 | 1–674 | P87-G/G-HD1 | PLpro |
| HD1 (Nsp1) | 675–2802 | ||
| Ac domain | 675–833 | ||
| PL1pro | 834–1040 | ||
| X domain | 1041–1194 | ||
| PL2 pro | 1201–1491 | ||
| Y domain | 1823–2288 | Y domain -G/G- P41 | PLpro |
| P41 | 2289–2802 | ||
| 3CL(Nsp2) | 2803–3109 | P41-Q/A-3CL | 3CLpro |
| HD2(Nsp3) | 3110–3403 | 3CL-Q/S-HD2 | 3CLpro |
| Nsp4 | 3404–3486 | HD2-Q/S-Nsp4 | 3CLpro |
| Nsp5 | 3487–3696 | Nsp4-Q/S-Nsp5 | 3CLpro |
| Nsp6 | 3697–3807 | Nsp5-Q/N-Nsp6 | 3CLpro |
| GLF(Nsp7) | 3808–3952 | Nsp6-Q/S-GLF | 3CLpro |
| Nsp8 | 3953–3975 | GLF-Q/S-23aac | 3CLpro |
| RdRp(Nsp9) | 3953–4892 | GLF-Q/S-RdRp | 3CLpro |
| Helicase(Nsp10) | 4893–5492 | RdRp-Q/S-Helicase | 3CLpro |
| ExoN(Nsp11) | 5493–6013 | Helicase-Q/G-Nsp11 | 3CLpro |
| XendoU(Nsp12) | 6014–6351 | Nsp11-Q/S-Nsp12 | 3CLpro |
| 2′-O-MT(Nsp13) | 6352–6653 | Nsp12-Q/S-Nsp13 | 3CLpro |